Acid Bacteria and Bifidobacteria as Vehicles of DNA Microbial Biosensors
Greg
May 24, 2021
Fluorescent Lactic Acid Micro organism and Bifidobacteria as Automobiles of DNA Microbial Biosensors
Administration and quantification of effector molecules comparable to heavy metals, toxins or totally different objective molecules is of good biotechnological, social and monetary curiosity. Microorganisms have regulatory proteins that acknowledge and modify the gene expression inside the presence or absence of these compounds (effector molecules) through binding to gene sequences. The affiliation of these recognizing gene sequences to reporter genes will allow the detection of effector molecules of curiosity with extreme sensitivity.
As quickly as investigators have these two elements-recognizing gene sequences and reporter genes that emit signals-we need an acceptable vehicle to introduce every elements. Proper right here, we suggest lactic acid micro organism (LAB) and bifidobacteria as promising service microorganisms for these molecular biosensors. Utilizing fluorescent proteins along with food-grade vectors and clustered repeatedly interspaced temporary palindromic repeats (CRISPR) are indispensable devices for introducing biosensors into these microorganisms. Utilizing these LAB and bifidobacteria could be of specific curiosity for studying the intestinal setting or totally different superior ecosystems.
The great variety of species tailor-made to many environments, along with the chance of creating use of a variety of protocols for his or her transformation with recognizing gene sequences and reporter genes are considerable advantages. Lastly, an effort must be made to go looking out recognizable gene sequences.
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 DNAAF5 Polyclonal Antibody |
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A58814-050 |
EpiGentek |
50 ul |
EUR 302.5 |
DNAAF5 Polyclonal Antibody |
|
A58814-100 |
EpiGentek |
100 ul |
EUR 423.5 |
DNAAF5 Polyclonal Antibody |
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A58814 |
EpiGentek |
-
EUR 684.66
-
EUR 117.70
-
EUR 302.50
-
EUR 423.50
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- 100 µg
- 20 ul
- 50 ul
- 100 ul
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 DNAAF5 Antibody, HRP conjugated |
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1-CSB-PA771471LB01HU |
Cusabio |
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Description: A polyclonal antibody against DNAAF5. Recognizes DNAAF5 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA |
 DNAAF5 Antibody, FITC conjugated |
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1-CSB-PA771471LC01HU |
Cusabio |
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Description: A polyclonal antibody against DNAAF5. Recognizes DNAAF5 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA |
 DNAAF5 Antibody, Biotin conjugated |
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1-CSB-PA771471LD01HU |
Cusabio |
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Description: A polyclonal antibody against DNAAF5. Recognizes DNAAF5 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA |
 DNAAF5 Polyclonal Antibody, Biotin Conjugated |
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A58815-050 |
EpiGentek |
50 ul |
EUR 302.5 |
DNAAF5 Polyclonal Antibody, Biotin Conjugated |
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A58815-100 |
EpiGentek |
100 ul |
EUR 423.5 |
 DNAAF5 Polyclonal Antibody, FITC Conjugated |
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A58816-050 |
EpiGentek |
50 ul |
EUR 302.5 |
DNAAF5 Polyclonal Antibody, FITC Conjugated |
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A58816-100 |
EpiGentek |
100 ul |
EUR 423.5 |
 DNAAF5 Polyclonal Antibody, HRP Conjugated |
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A58817-050 |
EpiGentek |
50 ul |
EUR 302.5 |
DNAAF5 Polyclonal Antibody, HRP Conjugated |
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A58817-100 |
EpiGentek |
100 ul |
EUR 423.5 |
DNAAF5 Polyclonal Antibody, Biotin Conjugated |
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A58815 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
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DNAAF5 Polyclonal Antibody, FITC Conjugated |
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A58816 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
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DNAAF5 Polyclonal Antibody, HRP Conjugated |
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A58817 |
EpiGentek |
-
EUR 684.66
-
EUR 302.50
-
EUR 423.50
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 ELISA Kit) Human Dynein Assembly Factor 5, Axonemal / HEATR2 (DNAAF5) ELISA Kit |
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abx387761-96tests |
Abbexa |
96 tests |
EUR 1093.2 |
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 ASAP1 antibody Antibody |
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DF8746 |
Affbiotech |
200ul |
EUR 420 |
 anti- Antibody^Polyclonal antibody control antibody |
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LSMab09882 |
Lifescience Market |
100 ug |
EUR 525.6 |
 Antibody) Anti-Glycolipid Antibody (AGA) Antibody |
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20-abx004855 |
Abbexa |
-
EUR 493.20
-
EUR 710.40
-
EUR 218.40
-
EUR 376.80
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- 100 ul
- 200 ul
- 20 ul
- 50 ul
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 Antibody) Ly1 Antibody Reactive (LYAR) Antibody |
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20-abx008109 |
Abbexa |
-
EUR 360.00
-
EUR 526.80
-
EUR 226.80
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Ly1 Antibody Reactive (LYAR) Antibody |
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20-abx123734 |
Abbexa |
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Ly1 Antibody Reactive (LYAR) Antibody |
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20-abx014333 |
Abbexa |
-
EUR 376.80
-
EUR 117.60
-
EUR 477.60
-
EUR 594.00
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- 100 ug
- 10 ug
- 200 ug
- 300 µg
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Ly1 Antibody Reactive (LYAR) Antibody |
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abx033330-400ul |
Abbexa |
400 ul |
EUR 627.6 |
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Ly1 Antibody Reactive (LYAR) Antibody |
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abx033330-80l |
Abbexa |
80 µl |
EUR 343.2 |
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Anti-Glycolipid Antibody (AGA) Antibody |
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abx036399-100ug |
Abbexa |
100 ug |
EUR 469.2 |
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 Antibody) Anti-Glycoprotein Antibody (GP) Antibody |
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20-abx319900 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
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EUR 218.40
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EUR 360.00
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- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
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Anti-Glycoprotein Antibody (GP) Antibody |
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20-abx319901 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
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- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
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Anti-Glycoprotein Antibody (GP) Antibody |
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20-abx319905 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
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EUR 718.80
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EUR 218.40
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EUR 360.00
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- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
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Anti-Glycoprotein Antibody (GP) Antibody |
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20-abx319913 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
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EUR 718.80
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EUR 218.40
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EUR 360.00
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- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
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Anti-Glycolipid Antibody (AGA) Antibody |
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abx230204-100ug |
Abbexa |
100 ug |
EUR 577.2 |
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Ly1 Antibody Reactive (LYAR) Antibody |
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20-abx324434 |
Abbexa |
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Ly1 Antibody Reactive (LYAR) Antibody |
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20-abx311665 |
Abbexa |
-
EUR 493.20
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EUR 2214.00
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EUR 718.80
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EUR 218.40
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EUR 360.00
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- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
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Ly1 Antibody Reactive (LYAR) Antibody |
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abx234901-100ug |
Abbexa |
100 ug |
EUR 661.2 |
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 Anti-Anti-SEPT6 antibody antibody |
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STJ11100949 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. |
 Anti-Anti-SEPT9 Antibody antibody |
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STJ111369 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described. |
 Anti-Anti-SEPT4 Antibody antibody |
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STJ112276 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer. |
 Anti-Anti-SEPT5 Antibody antibody |
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STJ114819 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
 Anti-Anti-SEPT7 Antibody antibody |
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STJ116214 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. |
 Anti-Anti-SEPT8 Antibody antibody |
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STJ117206 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
 Anti-Anti-SEPT12 Antibody antibody |
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STJ117759 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. |
Anti-Anti-SEPT7 Antibody antibody |
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STJ28963 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19. |
Anti-Anti-SEPT5 Antibody antibody |
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STJ25477 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. |
Anti-Anti-SEPT8 Antibody antibody |
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STJ25479 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
 Anti-Anti-SEPT1 antibody antibody |
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STJ119580 |
St John's Laboratory |
100 µl |
EUR 332.4 |
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Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012] |
 Cytokeratin 7 antibody-Cytoskeleton Marker Antibody |
|
48169-100ul |
SAB |
100ul |
EUR 399.6 |
Cytokeratin 7 antibody-Cytoskeleton Marker Antibody |
|
48169-50ul |
SAB |
50ul |
EUR 286.8 |
 Anti CD22 Antibody: CD22 Monoclonal Antibody |
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065-A-01mg |
Virogen |
0,1 mg |
EUR 321 |
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Description: anti-CD22 monoclonal antibody |
Anti CD22 Antibody: CD22 Monoclonal Antibody |
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065-A-1000ug |
Virogen |
1000 ug |
EUR 1539 |
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Description: anti-CD22 monoclonal antibody |
 Antibody Pair to ApoA-V antibody |
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10R-1876 |
Fitzgerald |
100 ul |
EUR 781.2 |
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Description: Mouse monoclonal Antibody Pair to ApoA-V antibody |
 Antibody) Ly1 Antibody Reactive Homolog (LYAR) Antibody |
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20-abx103034 |
Abbexa |
-
EUR 543.60
-
EUR 159.60
-
EUR 1562.40
-
EUR 744.00
-
EUR 410.40
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
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Ly1 Antibody Reactive Homolog (LYAR) Antibody |
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20-abx103035 |
Abbexa |
-
EUR 560.40
-
EUR 159.60
-
EUR 1612.80
-
EUR 760.80
-
EUR 410.40
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
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Ly1 Antibody Reactive Homolog (LYAR) Antibody |
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20-abx103036 |
Abbexa |
-
EUR 577.20
-
EUR 159.60
-
EUR 1696.80
-
EUR 794.40
-
EUR 427.20
|
- 100 ug
- 10 ug
- 1 mg
- 200 ug
- 50 ug
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 Antibody) Hepatitis C Virus Antibody (HCV) Antibody |
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abx023924-1mg |
Abbexa |
1 mg |
EUR 1446 |
|
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 Antibody (HRP)) Anti-Glycoprotein Antibody (GP) Antibody (HRP) |
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20-abx319902 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
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 Antibody (FITC)) Anti-Glycoprotein Antibody (GP) Antibody (FITC) |
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20-abx319903 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
 Antibody (Biotin)) Anti-Glycoprotein Antibody (GP) Antibody (Biotin) |
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20-abx319904 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
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Anti-Glycoprotein Antibody (GP) Antibody (HRP) |
|
20-abx319906 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
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Anti-Glycoprotein Antibody (GP) Antibody (FITC) |
|
20-abx319907 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
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Anti-Glycoprotein Antibody (GP) Antibody (Biotin) |
|
20-abx319908 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
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Anti-Glycoprotein Antibody (GP) Antibody (HRP) |
|
20-abx319914 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
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Anti-Glycoprotein Antibody (GP) Antibody (FITC) |
|
20-abx319915 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
Anti-Glycoprotein Antibody (GP) Antibody (Biotin) |
|
20-abx319916 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
Anti-Glycoprotein Antibody (GP) Antibody (HRP) |
|
20-abx319929 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
Anti-Glycoprotein Antibody (GP) Antibody (FITC) |
|
20-abx319930 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
Anti-Glycoprotein Antibody (GP) Antibody (Biotin) |
|
20-abx319931 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
 Antibody (HRP)) Ly1 Antibody Reactive (LYAR) Antibody (HRP) |
|
20-abx311666 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
 Antibody (FITC)) Ly1 Antibody Reactive (LYAR) Antibody (FITC) |
|
20-abx311667 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
 Antibody (Biotin)) Ly1 Antibody Reactive (LYAR) Antibody (Biotin) |
|
20-abx311668 |
Abbexa |
-
EUR 493.20
-
EUR 2214.00
-
EUR 718.80
-
EUR 218.40
-
EUR 360.00
|
- 100 ug
- 1 mg
- 200 ug
- 20 ug
- 50 ug
|
|
|
 Antibody) Anti-Glycoprotein 210 Antibody (gp210) Antibody |
|
abx233571-100ug |
Abbexa |
100 ug |
EUR 577.2 |
|
|
 Antibody) Anti Deoxyribonucleic Acid Antibody (DNA) Antibody |
|
abx411057-50ug |
Abbexa |
50 ug |
EUR 710.4 |
|
|
 Monoclonal NGF/proNGF Neutralizing Antibody Antibody |
|
AMM06679G |
Leading Biology |
0.05mg |
EUR 633.6 |
|
Description: A Monoclonal antibody against Human NGF/proNGF Neutralizing. The antibodies are raised in Mouse. This antibody is applicable in E |
 Goat anti- human Antibody^Polyclonal antibody |
|
LSMab09896 |
Lifescience Market |
100 ug |
EUR 525.6 |
 Antibody for Human alpha Tubulin Antibody |
|
SPC-692D |
Stressmarq |
0.1mg |
EUR 424.8 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is unconjugated. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-A390 |
Stressmarq |
0.1mg |
EUR 481.2 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 390. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-A488 |
Stressmarq |
0.1mg |
EUR 480 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 488. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-A565 |
Stressmarq |
0.1mg |
EUR 480 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 565. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-A594 |
Stressmarq |
0.1mg |
EUR 480 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 594. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-A633 |
Stressmarq |
0.1mg |
EUR 480 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 633. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-A655 |
Stressmarq |
0.1mg |
EUR 480 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 655. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-A680 |
Stressmarq |
0.1mg |
EUR 480 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 680. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-A700 |
Stressmarq |
0.1mg |
EUR 480 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to ATTO 700. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-ALP |
Stressmarq |
0.1mg |
EUR 472.8 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Alkaline Phosphatase. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-APC |
Stressmarq |
0.1mg |
EUR 478.8 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to APC . |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-APCCY7 |
Stressmarq |
0.1mg |
EUR 565.2 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to APC/Cy7. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-BI |
Stressmarq |
0.1mg |
EUR 475.2 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Biotin. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-DY350 |
Stressmarq |
0.1mg |
EUR 496.8 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Dylight 350. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-DY405 |
Stressmarq |
0.1mg |
EUR 483.6 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Dylight 405. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-DY488 |
Stressmarq |
0.1mg |
EUR 471.6 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Dylight 488. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-DY594 |
Stressmarq |
0.1mg |
EUR 474 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Dylight 594. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-DY633 |
Stressmarq |
0.1mg |
EUR 468 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Dylight 633. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-FITC |
Stressmarq |
0.1mg |
EUR 470.4 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to FITC. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-HRP |
Stressmarq |
0.1mg |
EUR 465.6 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to HRP. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-P594 |
Stressmarq |
0.1mg |
EUR 488.4 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to PE/ATTO 594. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-PCP |
Stressmarq |
0.1mg |
EUR 478.8 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to PerCP. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-RPE |
Stressmarq |
0.1mg |
EUR 476.4 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to RPE . |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692D-STR |
Stressmarq |
0.1mg |
EUR 477.6 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is conjugated to Streptavidin. |
Antibody for Human alpha Tubulin Antibody |
|
SPC-692S |
Stressmarq |
0.012mg |
EUR 78 |
|
Description: A polyclonal antibody for alpha Tubulin from Human. The antibody is produced in rabbit after immunization with human synthetic peptide of Human alpha-Tubulin. The Antibody is tested and validated for WB, ICC/IF assays with the following recommended dilutions: WB (1:1000); ICC/IF (1:100). This alpha Tubulin antibody is unconjugated. |
 Aggrecan antibody |
|
61-1049 |
Fitzgerald |
250 ug |
EUR 457.2 |
|
Description: Mouse Monoclonal Aggrecan antibody (Biotin) |
 Calcitonin antibody |
|
61-1050 |
Fitzgerald |
500 ug |
EUR 600 |
|
Description: Mouse Monoclonal Calcitonin antibody (Biotin) |
 HCG antibody |
|
61-1052 |
Fitzgerald |
500 ug |
EUR 457.2 |
|
Description: Mouse Monoclonal HCG antibody (Biotin) |
 Osteocalcin antibody |
|
61-1056 |
Fitzgerald |
250 ug |
EUR 457.2 |
|
Description: Mouse Monoclonal Osteocalcin antibody (Biotin) |
 ZIP12 Antibody |
|
6101-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: ZIP12 Antibody: The zinc transporter ZIP12, also known as SLC39A12, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP12 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Increased levels of ZIP12 have been observed during acute inflammation in the airway and asthma, suggesting that it may be promote increased zinc uptake, as this can reduce inflammation. The zinc content in brains in individuals with schizophrenia is lower than in individuals with other cerebral diseases, and mutations in ZIP12 have been observed in a small group of schizophrenic patients, suggesting that ZIP12 may play a role in this disease. |
ZIP12 Antibody |
|
6101-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: ZIP12 Antibody: The zinc transporter ZIP12, also known as SLC39A12, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP12 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Increased levels of ZIP12 have been observed during acute inflammation in the airway and asthma, suggesting that it may be promote increased zinc uptake, as this can reduce inflammation. The zinc content in brains in individuals with schizophrenia is lower than in individuals with other cerebral diseases, and mutations in ZIP12 have been observed in a small group of schizophrenic patients, suggesting that ZIP12 may play a role in this disease. |
 ZIP13 Antibody |
|
6103-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: ZIP13 Antibody: The zinc transporter ZIP13, also known as SLC39A13, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP13 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Mutations in ZIP13 have recently been shown to cause a spondylocheiro dysplastic form of Ehlers-Danlos syndrome (SCD-EDS), a generalized skeletal dysplasia involving mainly the spine with clinical abnormalities of the hands in addition to EDS-like features. Other experiments have shown that ZIP13 is required for proper connective tissue development and is involved in BMP/TGF- signaling pathways. |
ZIP13 Antibody |
|
6103-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: ZIP13 Antibody: The zinc transporter ZIP13, also known as SLC39A13, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP13 is a multipass membrane protein that belongs to the ZIP transporter subfamily LIV-1. Mutations in ZIP13 have recently been shown to cause a spondylocheiro dysplastic form of Ehlers-Danlos syndrome (SCD-EDS), a generalized skeletal dysplasia involving mainly the spine with clinical abnormalities of the hands in addition to EDS-like features. Other experiments have shown that ZIP13 is required for proper connective tissue development and is involved in BMP/TGF- signaling pathways. |
 ZIP14 Antibody |
|
6105-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: ZIP14 Antibody: The zinc transporter ZIP14, also known as SLC39A14, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP14 is a glycosylated multipass plasma membrane protein that belongs to the ZIP transporter subfamily LIV-1. ZIP14 has been shown to contribute to the hypozincemia of inflammation and infection and is regulated in the liver by IL-6. In addition to zinc, ZIP14 is also involved in the cellular uptake of non-transferrin-bound iron as well as iron bound to transferrin. |
ZIP14 Antibody |
|
6105-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: ZIP14 Antibody: The zinc transporter ZIP14, also known as SLC39A14, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP14 is a glycosylated multipass plasma membrane protein that belongs to the ZIP transporter subfamily LIV-1. ZIP14 has been shown to contribute to the hypozincemia of inflammation and infection and is regulated in the liver by IL-6. In addition to zinc, ZIP14 is also involved in the cellular uptake of non-transferrin-bound iron as well as iron bound to transferrin. |
 KLOTHO Antibody |
|
6107-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: KLOTHO Antibody: KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor. |
KLOTHO Antibody |
|
6107-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: KLOTHO Antibody: KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor. |
 REQUIEM Antibody |
|
6109-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: REQUIEM Antibody: Requiem is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It is expressed in numerous tissues in both cytosolic and nuclear regions and likely serves a regulatory role in rapid hematopoietic cell growth and turnover. Requiem has been found to act as an adaptor protein that links the NF-κB and SWI/SNF chromatin remodeling factor and is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. |
REQUIEM Antibody |
|
6109-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: REQUIEM Antibody: Requiem is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It is expressed in numerous tissues in both cytosolic and nuclear regions and likely serves a regulatory role in rapid hematopoietic cell growth and turnover. Requiem has been found to act as an adaptor protein that links the NF-κB and SWI/SNF chromatin remodeling factor and is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. |
 CXXC5 Antibody |
|
6111-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: CXXC5 Antibody: CXXC5 is zinc finger protein closely related to the DVL1-binding protein CXXC4 (also known as Idax), and like CXXC4 is thought to modulate the Wnt signaling pathway during development. CXXC5 is upregulated in neural stem cells upon BMP4 stimulation, leading to decreased levels of the Wnt-signaling target AXIN2 and facilitated the response of the stem cells to Wnt3a. Recent reports suggest CXXC5 transcription is activated by the Wilms tumor 1 (WT1) transcription factor, and together are involved in the WNT/beta-catenin pathway and play a role in embryonic kidney development. |
CXXC5 Antibody |
|
6111-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: CXXC5 Antibody: CXXC5 is zinc finger protein closely related to the DVL1-binding protein CXXC4 (also known as Idax), and like CXXC4 is thought to modulate the Wnt signaling pathway during development. CXXC5 is upregulated in neural stem cells upon BMP4 stimulation, leading to decreased levels of the Wnt-signaling target AXIN2 and facilitated the response of the stem cells to Wnt3a. Recent reports suggest CXXC5 transcription is activated by the Wilms tumor 1 (WT1) transcription factor, and together are involved in the WNT/beta-catenin pathway and play a role in embryonic kidney development. |
 TFF3 Antibody |
|
6113-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: TFF3 Antibody: Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. Trefoil peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain and clustered in human chromosome 21q22.3. Trefoil Factor 3 (TFF3) is one of three trefoil peptides secreted by epithelial cells that line mucus membranes in the large and small intestines and lower respiratory tract. TFF3 is mainly active as a disulfide-linked homodimer and may have a role in promoting cell migration in healing processes. It is involved in the maintenance and repair of the intestinal mucosa. |
TFF3 Antibody |
|
6113-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: TFF3 Antibody: Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. Trefoil peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain and clustered in human chromosome 21q22.3. Trefoil Factor 3 (TFF3) is one of three trefoil peptides secreted by epithelial cells that line mucus membranes in the large and small intestines and lower respiratory tract. TFF3 is mainly active as a disulfide-linked homodimer and may have a role in promoting cell migration in healing processes. It is involved in the maintenance and repair of the intestinal mucosa. |
 WIZ Antibody |
|
6117-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: WIZ Antibody: WIZ, also known as ZNF803, was initially identified in a mouse cerebellum cDNA library screen and its message was found to be expressed in the granule cell layers of the cerebellum as well as in the dentate gyrus and olfactory bulb. Later analysis indicates however that WIZ is ubiquitously expressed. WIZ is a nuclear protein that co-localizes with G9a, a histone methyltransferase responsible for mono- and dimethylation of H3K9 at euchromatic regions. WIZ can also associate with CtBP family proteins, known to be transcriptional co-repressors, and has been suggested to link G9a/GLP complexes to the CtBP co-repressor machinery, possibly regulating complex stability and gene silencing. |
WIZ Antibody |
|
6117-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: WIZ Antibody: WIZ, also known as ZNF803, was initially identified in a mouse cerebellum cDNA library screen and its message was found to be expressed in the granule cell layers of the cerebellum as well as in the dentate gyrus and olfactory bulb. Later analysis indicates however that WIZ is ubiquitously expressed. WIZ is a nuclear protein that co-localizes with G9a, a histone methyltransferase responsible for mono- and dimethylation of H3K9 at euchromatic regions. WIZ can also associate with CtBP family proteins, known to be transcriptional co-repressors, and has been suggested to link G9a/GLP complexes to the CtBP co-repressor machinery, possibly regulating complex stability and gene silencing. |
 ZBTB3 Antibody |
|
6119-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: ZBTB3 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. While little is known about ZBTB3, the related protein ZBTB2 is thought to be phosphorylated in response to the DNA damage, probably by either ATM or ATR. Other ZBTB proteins, such as ZBTB4 and ZBTB38 bind methylated DNA and repress transcription, suggesting that ZBTB3 may also act as a transcription repressor. |
ZBTB3 Antibody |
|
6119-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: ZBTB3 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. While little is known about ZBTB3, the related protein ZBTB2 is thought to be phosphorylated in response to the DNA damage, probably by either ATM or ATR. Other ZBTB proteins, such as ZBTB4 and ZBTB38 bind methylated DNA and repress transcription, suggesting that ZBTB3 may also act as a transcription repressor. |
 ZBTB4 Antibody |
|
6121-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: ZBTB4 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage. |
ZBTB4 Antibody |
|
6121-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: ZBTB4 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. Similar to Kaiso, a zinc-finger containing protein that can bind methylated CpGs, ZBTB4 can also bind methylated DNA and repress transcription. ZBTB4 has been shown to associate with the Sin3/histone deacetylase co-repressor and repress expression of P21CIP1 as part of a heterodimeric complex with Miz1. In cultured cells, depletion of ZBTB4 promotes cell cycle arrest in response to p53 activation and suppresses apoptosis through regulation of P21CIP1, suggesting that ZBTB4 is a critical determinant of the cellular response to p53 activation. HIPK2, a kinase that is involved in cellular proliferation and survival, phosphorylates and down-regulates ZBTB4 under normal cell growth conditions; this degradation increases with DNA damage. |
 ZBTB5 Antibody |
|
6123-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: ZBTB5 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB5 was identified though sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. Further experiments indicated that it binds DNA and can directly repress transcription of the cell cycle arrest gene p21. ZBTB5 can also interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene. |
ZBTB5 Antibody |
|
6123-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: ZBTB5 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB5 was identified though sequence analysis as a POZ domain Kruppel-like zinc finger (POK) protein. Further experiments indicated that it binds DNA and can directly repress transcription of the cell cycle arrest gene p21. ZBTB5 can also interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, resulting in deacetylation of histones Ac-H3 and Ac-H4 at the proximal promoter. ZBTB5 stimulates both cell proliferation and cell cycle progression, suggesting that it may act as a potential proto-oncogene. |
 ZBTB6 Antibody |
|
6125-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: ZBTB6 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB6, also known as ZNF482, is highly expressed in brain. While little is known about ZBTB6, other ZBTB proteins, such as ZBTB4 bind methylated DNA and repress transcription. Another ZBTB family member, ZBTB5, also acts as a transcriptional repressor, and can interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, suggesting that ZBTB6 may also act as a transcriptional repressor. |
ZBTB6 Antibody |
|
6125-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: ZBTB6 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB6, also known as ZNF482, is highly expressed in brain. While little is known about ZBTB6, other ZBTB proteins, such as ZBTB4 bind methylated DNA and repress transcription. Another ZBTB family member, ZBTB5, also acts as a transcriptional repressor, and can interact with co-repressor histone deacetylase complexes such as BCoR, NCoR, and SMRT via its POZ domain, suggesting that ZBTB6 may also act as a transcriptional repressor. |
 ZBTB7A Antibody |
|
6127-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
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Description: ZBTB7A Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB7A, also known as LRF, was initially identified as a potential target of the LAZ-3/BCL-6 oncogene. Later reports demonstrated that it could bind to the wild-type IST (inducer of short transcripts) elements of HIV-1 long terminal repeats (LTRs) and stimulate Tat activity on the HIV-1 LTR. More recently it ZBTB7A has been recognized as a proto-oncogene whose overexpression contributes to malignancy in breast cancer and functions as a co-repressor of the androgen receptor in prostate cancer cells. |
ZBTB7A Antibody |
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6127-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
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Description: ZBTB7A Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB7A, also known as LRF, was initially identified as a potential target of the LAZ-3/BCL-6 oncogene. Later reports demonstrated that it could bind to the wild-type IST (inducer of short transcripts) elements of HIV-1 long terminal repeats (LTRs) and stimulate Tat activity on the HIV-1 LTR. More recently it ZBTB7A has been recognized as a proto-oncogene whose overexpression contributes to malignancy in breast cancer and functions as a co-repressor of the androgen receptor in prostate cancer cells. |
 ZBTB8 Antibody |
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6129-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
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Description: ZBTB8 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB8, also known as BOZ-F1, is present in multiple tissues, and is highly expressed in the cytoplasm of the placenta. While little is known about ZBTB8, other ZBTB proteins, such as ZBTB4 bind methylated DNA and repress transcription. Another ZBTB proteins, ZBTB7A, has been implicated as a proto-oncogene whose overexpression contributes to malignancy in breast cancer, suggesting that ZBTB8 may act as a transcriptional repressor or be involved in tumorigenesis. |
ZBTB8 Antibody |
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6129-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
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Description: ZBTB8 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB8, also known as BOZ-F1, is present in multiple tissues, and is highly expressed in the cytoplasm of the placenta. While little is known about ZBTB8, other ZBTB proteins, such as ZBTB4 bind methylated DNA and repress transcription. Another ZBTB proteins, ZBTB7A, has been implicated as a proto-oncogene whose overexpression contributes to malignancy in breast cancer, suggesting that ZBTB8 may act as a transcriptional repressor or be involved in tumorigenesis. |
 ZBTB9 Antibody |
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6131-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
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Description: ZBTB9 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB9, also known as ZNF919, is present in multiple tissues, and is highly expressed in the cytoplasm of the placenta. While little is known about ZBTB9, other ZBTB proteins, such as ZBTB4 bind methylated DNA and repress transcription. Another ZBTB proteins, ZBTB7A, has been implicated as a proto-oncogene whose overexpression contributes to malignancy in breast cancer, suggesting that ZBTB9 may act as a transcriptional repressor or be involved in tumorigenesis. |
ZBTB9 Antibody |
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6131-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
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Description: ZBTB9 Antibody: The ZBTB family of proteins is comprised of diverse zinc finger proteins that also contain a BTB (BR-C, ttk and bab) domain. ZBTB9, also known as ZNF919, is present in multiple tissues, and is highly expressed in the cytoplasm of the placenta. While little is known about ZBTB9, other ZBTB proteins, such as ZBTB4 bind methylated DNA and repress transcription. Another ZBTB proteins, ZBTB7A, has been implicated as a proto-oncogene whose overexpression contributes to malignancy in breast cancer, suggesting that ZBTB9 may act as a transcriptional repressor or be involved in tumorigenesis. |
 ZMYM1 Antibody |
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6133-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
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Description: ZMYM1 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM1 is widely expressed in different tissues in eukaryotes under several forms derived by alternative splicing. While its function remains unknown, the related protein ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes, suggesting that ZMYM1 may play a similar role. |
ZMYM1 Antibody |
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6133-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
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Description: ZMYM1 Antibody: Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM1 is widely expressed in different tissues in eukaryotes under several forms derived by alternative splicing. While its function remains unknown, the related protein ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes, suggesting that ZMYM1 may play a similar role. |
Irregular Homocysteine Metabolism: An Notion of Alzheimer’s Sickness from DNA Methylation
Alzheimer’s sickness (AD) is a persistent neurodegenerative sickness inside the central nervous system that has superior pathogenesis inside the aged. The current analysis focuses on the epigenetic mechanisms of AD, in response to the most recent findings. The best-characterized chromatin modifications in epigenetic mechanisms is DNA methylation. Extraordinarily replicable data reveals that AD incidence is often accompanied by methylation diploma changes of the AD-related gene.
Homocysteine (Hcy) is simply not solely an intermediate product of one-carbon metabolism however as well as an important neutral hazard concern of AD; it could probably affect the cognitive carry out of the thoughts by altering the one-carbon metabolism and interfering with the DNA methylation course of, resulting in cerebrovascular sickness.
Often, Hcy may be an environmental concern that impacts AD by means of the DNA methylation pathway with a group of changes in AD-related substance. This analysis will take into consideration the relation between DNA methylation and Hcy and try to find out their rule inside the pathophysiology of AD.
TET is focused for proteasomal degradation by the PHD-pVHL pathway to scale back DNA hydroxymethylation
Hypoxia-inducible elements are heterodimeric transcription elements that play an necessary place in a cell’s functionality to adapt to low oxygen. The von-Hippel Lindau tumor suppressor (pVHL), acts as a grasp regulator of HIF train, and its specializing in of prolyl hydroxylated HIF-α for proteasomal degradation beneath normoxia is taken into account a big mechanism for pVHL tumor suppression and cellular response to oxygen.
Whether or not or not pVHL regulates totally different targets by the identical mechanism is actually unknown. Proper right here, we decide TET2/Three as novel targets of pVHL. pVHL induces proteasomal degradation of TET2/3, resulting in decreased worldwide 5-hydroxymethylcytosine ranges.
Conserved proline residues contained in the LAP/LAP-like motifs of these two proteins are hydroxylated by the prolyl hydroxylase enzymes (PHD2/EGLN1 and PHD3/EGLN3), which is prerequisite for pVHL-mediated degradation. Using zebrafish as a model, we determined that worldwide 5-hydroxymethylcytosine ranges are enhanced in vhl-null, egln1a/b-double null and egln3-null embryos.
Subsequently, we reveal a novel carry out for the PHD-pVHL pathway in regulating TET protein stability and train. These data lengthen our understanding of how TET proteins are regulated and provide new notion into the mechanisms of pVHL in tumor suppression.
Degree-of-care DNA testing by routinely and sequentially performing extraction, amplification and identification in a closed-type cassette
- Nucleic acid detection is important for scientific diagnostics; nonetheless, it is tough to hold out genetic testing on the point-of-care due to the tedious steps involved in DNA extraction and the prospect of cross-contamination from amplicons.
- To comprehend a fully-automated and contamination-free nucleic acid detection, we propose a closed-type cassette system which permits the following steps to be operated routinely and sequentially: sample preparation primarily based totally on magnetic beads, objective amplification using multiplex polymerase chain response, and colorimetric detection of amplicons using a serial invasive response coupled with the aggregation of gold nanoparticle probes.
- The cassette was designed to be spherical and closed, and 10 targets in a sample is perhaps concurrently detected by the naked eye or using a spectrophotometer inside the system.
- In addition to, a cassette-driven system was fabricated to modify reagents between wells, to manage the temperature of each response, and to sense the colour inside the detection wells. The cassette system was delicate adequate to detect 10 genotypes at 5 single nucleotide polymorphism web sites related to the anticoagulant’s utilization, via using a 0.5 µL blood sample.
- The accuracy of the system was evaluated by detecting 12 total blood samples, and the outcomes obtained have been in line with these obtained using pyrosequencing. The cassette is airtight and the complete system is totally computerized; the one information operation is the addition of the sample to the cassette, performing point-of-care genetic testing in a sample-in/answer-out means.
