Maintenance of DNMT1-Mediated DNA Methylation Patterns

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Stearoyl-CoA Desaturase 1 Exercise Determines the Upkeep of DNMT1-Mediated DNA Methylation Patterns in Pancreatic β-Cells

Metabolic stress, comparable to lipotoxicity, impacts the DNA methylation profile in pancreatic β-cells and thus contributes to β-cell failure and the event of kind 2 diabetes (T2D).

Stearoyl-CoA desaturase 1 (SCD1) is a rate-limiting enzyme that is involved in monounsaturated fatty acid synthesis, which protects pancreatic β-cells in the direction of lipotoxicity. The present analysis found that SCD1 can be required for the establishment and maintenance of DNA methylation patterns in β-cells.

  • We confirmed that SCD1 inhibition/deficiency prompted DNA hypomethylation and adjusted the methyl group distribution inside chromosomes in β-cells. Lower ranges of DNA methylation in SCD1-deficient β-cells have been adopted by lower ranges of DNA methyltransferase 1 (DNMT1).
  • We moreover found that the downregulation of SCD1 in pancreatic β-cells led to the activation of adenosine monophosphate-activated protein kinase (AMPK) and an increase inside the train of the NAD-dependent deacetylase sirtuin-1 (SIRT1).
  • Furthermore, the bodily affiliation between DNMT1 and SIRT1 stimulated the deacetylation of DNMT1 beneath circumstances of SCD1 inhibition/downregulation, suggesting a mechanism by which SCD1 exerts administration over DNMT1.
  • We moreover found that SCD1-deficient β-cells which were dealt with with compound c, an inhibitor of AMPK, have been characterised by bigger ranges of every worldwide DNA methylation and DNMT1 protein expression in distinction with untreated cells.
  • Subsequently, we found that activation of the AMPK/SIRT1 signaling pathway mediates the affect of SCD1 inhibition/deficiency on DNA methylation standing in pancreatic β-cel
  • Altogether, these findings suggest that SCD1 is a gatekeeper that protects β-cells in the direction of the lipid-derived lack of DNA methylation and provide mechanistic insights into the mechanism by which SCD1 regulates DNA methylation patterns in β-cells and T2D-relevant tissues.
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hsa-mir-25 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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hsa-mir-26a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

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  • 200 rxns
  • 50 rxns

hsa-mir-30e Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097651
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-31 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097652
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-32 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097653
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-33a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097654
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-34a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097657
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-34b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097659
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-92a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097661
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-92b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097662
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-93 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097663
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-95 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097664
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-96 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097665
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-98 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097666
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-99a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097667
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-99b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097669
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-100 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097671
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-101 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097673
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-103 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097675
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-105 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097676
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-106a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097677
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-106b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097678
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-107 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097679
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-124 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097680
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-125a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097681
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-127 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097686
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-129 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097689
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-130a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097690
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-130b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097691
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-132 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097692
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-133a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097693
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-133b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097694
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-134 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097695
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-135b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097696
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-137 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097699
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-138 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097700
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-139 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097701
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-140 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097702
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-141 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097703
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-143 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097706
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-145 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097708
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-146a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097709
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-149 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097711
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-150 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097712
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-151 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097714
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-152 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097715
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-153 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097716
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-154 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097717
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-181a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097719
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-181b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097720
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-181c Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097721
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-181d Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097722
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-182 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097723
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-183 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097724
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-184 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097725
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-185 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097726
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-190a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097728
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-190b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097729
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-192 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097731
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-193a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097732
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-193b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097733
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-194 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097734
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-195 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097735
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-197 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097738
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-198 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097739
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-199a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097740
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-199b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097741
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-200a Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097742
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-200b Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097743
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-202 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097745
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

hsa-mir-203 Real-Time RT-PCR Detection and cel-mir-39-3p Calibration Kit

20-abx097746
  • EUR 878.40
  • EUR 1245.60
  • EUR 627.60
  • 100 rxns
  • 200 rxns
  • 50 rxns

Circulating Vitamin D Ranges and DNA Restore Capability in 4 Molecular Subtypes of Girls with Breast Most cancers

Vitamin D regulates estrogen synthesis amongst completely different mechanisms involved in breast most cancers (BC) progress; nonetheless, no proof has been found regarding its relationship with DNA restore functionality (DRC). Subsequently, the goal of this analysis was to elucidate whether or not or not DRC ranges are linked with plasma 25(OH)D ranges.

  • BC circumstances and controls have been chosen from our BC cohort. DRC ranges have been assessed in lymphocytes by the host-cell reactivation assay. 25(OH)D ranges have been measured using the UniCel DxI 600 Entry Immunoassay System. BC circumstances (n = 91) confirmed bigger 25(OH)D ranges than the controls (n = 92) (p = 0.001).
  • When stratifying BC circumstances and controls into excessive and low DRC lessons, BC circumstances with low DRC (n = 74) had one of the best 25(OH)D ranges (p = 0.0001).
  • A constructive correlation between 25(OH)D and DRC ranges was found for the controls (r = 0.215, p = 0.043) whereas a harmful correlation was found for BC circumstances (r = -0.236, p = 0.026). Essential variations in 25(OH)D ranges have been seen when stratifying by molecular subtypes (p = 0.0025).
  • Our analysis provides proof of a hyperlink between 25(OH)D and DRC in BC along with a top level view of to how 25(OH)D ranges fluctuate all through subtypes. The constructive correlation seen inside the administration group signifies that 25(OH)D contributes otherwise to DRC ranges as quickly because the malignancy is developed.

Intercourse-specific associations with DNA methylation in lung tissue present smoking interactions

Cigarette smoking impacts DNA methylation, nevertheless the investigation of sex-specific choices of lung tissue DNA methylation in individuals who smoke has been restricted. Women appear additional vulnerable to cigarette smoke, and generally develop additional excessive lung sickness at an earlier age with a lot much less smoke publicity.

We aimed to analyse whether or not or not there are intercourse variations in DNA methylation in lung tissue and whether or not or not these DNA methylation marks work along with smoking. We collected lung tissue samples from former individuals who smoke who underwent lung tissue resection. 100 thirty samples from white subjects have been included for this analysis. Regression fashions for intercourse as a predictor of methylation have been adjusted for age, presence of COPD, smoking variables and technical batch variables revealed 710 associated web sites.

294 web sites demonstrated sturdy sex-specific methylation associations in foetal lung tissue. Pathway analysis acknowledged 6 nominally very important pathways along with the mitophagy pathway. Three CpG web sites demonstrated a urged interaction between intercourse and pack-years of smoking: GPR132, ANKRD44 and C19orf60.

All of them have been nominally very important in every male- and female-specific fashions, and the affect estimates have been in reverse directions for feminine and male; GPR132 demonstrated very important affiliation between DNA methylation and gene expression in lung tissue (P< 0.05). Intercourse-specific associations with DNA methylation in lung tissue are wide-spread and can reveal genes and pathways associated to intercourse variations for lung damaging outcomes of cigarette smoking.

Environment friendly detection of eukaryotic calcium-sensing receptor (CaSR) by polyclonal antibody towards prokaryotic expressed truncated CaSR

 The calcium-sensing receptor (CaSR), which is best identified for its motion as regulating calcium homeostasis, can bind numerous ligands. To facilitate analysis on CaSR and perceive the receptor’s perform additional, an in silico designed truncated protein was developed. The ensuing protein folding indicated that 99% of predicted three dimensional (3D) construction residues are positioned in favored and allowed Ramachandran plots. Nevertheless, it was discovered that such protein doesn’t fold correctly when expressed in prokaryotic host cells.

Thioredoxin (Trx) tag was conjugated to extend the ultimate protein’s solubility, which might assist get hold of the soluble antigen with higher immunogenic properties. The truncated recombinant proteins have been expressed and purified in two varieties (Trx-CaSR: RR19 and CaSR: RRJ19). The polyclonal antibody was induced by the rabbit immunization with the type of RR19. Western blot on mouse kidney lysates evidenced the right immune recognition of the receptor by the produced antibody.

The specificity and sensitivity of antibodies have been additionally assayed by immunohistofluorescence. These experiments affirmed antibody’s capacity to point the receptor on the cell floor in native type and the opportunity of making use of such antibodies in additional mobile and tissue assays.

GPCR RDC1 Antibody

49041-100ul 100ul
EUR 399.6

GPCR RDC1 Antibody

49041-50ul 50ul
EUR 286.8

GPCR GPR65 Antibody

DF13937 100ul
EUR 420

GPCR TGR5 Antibody

DF14067 100ul
EUR 420

anti-GPCR GPR146

YF-PA21926 100 ug
EUR 483.6
Description: Rabbit polyclonal to Anti-GPCR GPR146

anti-GPCR MRGX2

YF-PA22009 50 ug
EUR 435.6
Description: Mouse polyclonal to Anti-GPCR MRGX2

anti-GPCR LOC51210

YF-PA22204 50 ul
EUR 435.6
Description: Mouse polyclonal to GPCR LOC51210

anti-GPCR LOC51210

YF-PA22205 50 ug
EUR 435.6
Description: Mouse polyclonal to GPCR LOC51210

anti-GPCR LOC51210

YF-PA22206 100 ul
EUR 483.6
Description: Rabbit polyclonal to GPCR LOC51210

anti-GPCR LOC51210

YF-PA22207 100 ug
EUR 483.6
Description: Rabbit polyclonal to GPCR LOC51210

anti-GPCR 2037

YF-PA22241 50 ug
EUR 435.6
Description: Mouse polyclonal to Anti-GPCR 2037

anti-GPCR GPR110

YF-PA22867 50 ul
EUR 435.6
Description: Mouse polyclonal to GPCR GPR110

anti-GPCR GPR110

YF-PA22868 50 ug
EUR 435.6
Description: Mouse polyclonal to GPCR GPR110

anti-GPCR GPR3

YF-PA23809 50 ul
EUR 400.8
Description: Mouse polyclonal to GPCR GPR3

anti-GPCR GPR3

YF-PA12103 50 ug
EUR 435.6
Description: Mouse polyclonal to GPCR GPR3

anti-GPCR GPR34

YF-PA12105 50 ug
EUR 435.6
Description: Mouse polyclonal to GPCR GPR34

anti-GPCR C5L2

YF-PA18412 50 ug
EUR 435.6
Description: Mouse polyclonal to GPCR C5L2

anti-GPCR SALPR

YF-PA18968 50 ul
EUR 435.6
Description: Mouse polyclonal to GPCR SALPR

anti-GPCR GPRC5D

YF-PA19735 50 ug
EUR 435.6
Description: Mouse polyclonal to GPCR GPRC5D

anti-GPCR GPR62

YF-PA26842 50 ul
EUR 400.8
Description: Mouse polyclonal to GPCR GPR62

anti-GPCR LOC51210

YF-PA26875 50 ul
EUR 400.8
Description: Mouse polyclonal to GPCR LOC51210

anti-GPCR HM74

YF-PA15914 50 ug
EUR 435.6
Description: Mouse polyclonal to GPCR HM74

anti-GPCR SALPR

YF-PA26165 50 ul
EUR 400.8
Description: Mouse polyclonal to GPCR SALPR

anti-GPCR EX33

YF-PA26233 50 ul
EUR 400.8
Description: Mouse polyclonal to GPCR EX33

anti-GPCR GPRC5D

YF-PA26334 50 ul
EUR 400.8
Description: Mouse polyclonal to GPCR GPRC5D

anti-GPCR LGR7

YF-PA26522 50 ul
EUR 400.8
Description: Mouse polyclonal to GPCR LGR7

anti-GPCR LGR6

YF-PA26523 50 ul
EUR 400.8
Description: Mouse polyclonal to GPCR LGR6

anti-GPCR TAS1R1

YF-PA26658 50 ul
EUR 400.8
Description: Mouse polyclonal to GPCR TAS1R1

Anti-D-GPCR Antibody

A12058 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for D-GPCR Antibody (OR51E1) detection.tested for WB in Human.

D-GPCR Polyclonal Antibody

ABP51168-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of D-GPCR from Human. This D-GPCR antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human D-GPCR at AA range: 210-290

D-GPCR Polyclonal Antibody

ABP51168-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of D-GPCR from Human. This D-GPCR antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human D-GPCR at AA range: 210-290

D-GPCR Polyclonal Antibody

ABP51168-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of D-GPCR from Human. This D-GPCR antibody is for WB, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human D-GPCR at AA range: 210-290

GPCR GPR86 Conjugated Antibody

C48382 100ul
EUR 476.4

GPCR RDC1 Conjugated Antibody

C49041 100ul
EUR 476.4

D-GPCR Polyclonal Antibody

ES2167-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against D-GPCR from Human. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

D-GPCR Polyclonal Antibody

ES2167-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against D-GPCR from Human. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

Porcine GPCR ELISA Kit

EPG0026 96Tests
EUR 625.2

Rabbit GPCR ELISA Kit

ERTG0026 96Tests
EUR 625.2

Rat GPCR ELISA Kit

ERG0026 96Tests
EUR 625.2

Mouse GPCR ELISA Kit

EMG0026 96Tests
EUR 625.2

Monkey GPCR ELISA Kit

EMKG0026 96Tests
EUR 625.2

Human GPCR ELISA Kit

EHG0026 96Tests
EUR 625.2

Goat GPCR ELISA Kit

EGTG0026 96Tests
EUR 625.2

Bovine GPCR ELISA Kit

EBG0026 96Tests
EUR 625.2

Canine GPCR ELISA Kit

ECG0026 96Tests
EUR 625.2

Chicken GPCR ELISA Kit

ECKG0026 96Tests
EUR 625.2

DiscoveryProbe? GPCR Compound Library

L1025-.1 100 uL/well(10 mM solution)
EUR 5683.2

DiscoveryProbe? GPCR Compound Library

L1025-.25 250 uL/well(10 mM solution)
EUR 10221.6

DiscoveryProbe? GPCR Compound Library

L1025-5 5 mg/well
EUR 13284

Sheep GPCR ELISA Kit

ESG0026 96Tests
EUR 625.2

Anti-D-GPCR antibody

STJ92705 200 µl
EUR 236.4
Description: Rabbit polyclonal to D-GPCR.

Anti-GPCR GPR40 Antibody

STJ501005 100 µg
EUR 571.2

Anti-GPCR GPR3 Antibody

STJ501253 100 µg
EUR 571.2

Anti-GPCR SALPR (1F10)

YF-MA18467 100 ug
EUR 435.6
Description: Mouse monoclonal to GPCR SALPR

Anti-GPCR EX33 (5C3)

YF-MA18601 100 ug
EUR 435.6
Description: Mouse monoclonal to GPCR EX33

Anti-GPCR EX33 (5B7)

YF-MA18602 100 ug
EUR 435.6
Description: Mouse monoclonal to GPCR EX33

Anti-GPCR EX33 (1D9)

YF-MA18603 100 ug
EUR 435.6
Description: Mouse monoclonal to GPCR EX33

Anti-GPCR GPR48 (8F6)

YF-MA18780 100 ug
EUR 435.6
Description: Mouse monoclonal to GPCR GPR48

Anti-GPCR GPRC5D (6D9)

YF-MA18788 100 ug
EUR 435.6
Description: Mouse monoclonal to GPCR GPRC5D

Anti-GPCR LOC51210 (6D7)

YF-MA19845 100 ug
EUR 435.6
Description: Mouse monoclonal to GPCR LOC51210

Anti-GPCR LGR7 (3E3)

YF-MA11622 100 ug
EUR 435.6
Description: Mouse monoclonal to GPCR LGR7

Anti-GPCR GPR40/FFAR1 Antibody

A01349-2 100ug/vial
EUR 352.8

Anti-GPCR LGR8/RXFP2 Antibody

A04848-1 100ug/vial
EUR 400.8

Anti-LGR6/Gpcr Lgr6 Antibody

A05990 100ul
EUR 476.4
Description: Rabbit Polyclonal LGR6/Gpcr Lgr6 Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-GPCR GPR7/NPBWR1 Antibody

A08247-1 100ug/vial
EUR 352.8

Anti-GPR151/Gpcr 2037 Antibody

A14582 100ul
EUR 476.4
Description: Rabbit Polyclonal GPR151/Gpcr 2037 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-GPR151/Gpcr 2037 Antibody

A30814 100ul
EUR 476.4
Description: Rabbit Polyclonal GPR151/Gpcr 2037 Antibody. Validated in IF, WB and tested in Mouse, Rat.

Guinea Pig GPCR ELISA Kit

EGG0026 96Tests
EUR 625.2

Anserini GPCR-APJ ELISA Kit

EAG0026 96Tests
EUR 625.2

Anti-GPCR GPR40 Antibody BIOTIN

STJ501006 100 µg
EUR 703.2

Anti-GPCR GPR40 Antibody FITC

STJ501007 100 µg
EUR 703.2

Anti-GPCR GPR3 Antibody BIOTIN

STJ501254 100 µg
EUR 703.2

Anti-GPCR GPR3 Antibody FITC

STJ501255 100 µg
EUR 703.2

anti-5-oxo-ETE GPCR

YF-PA22585 50 ug
EUR 435.6
Description: Mouse polyclonal to 5-oxo-ETE GPCR

Phosphatase Orphan-2 (Recombinant)

20-abx073747
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Phosphatase Orphan-1 (Recombinant)

20-abx073910
  • EUR 393.60
  • EUR 8829.60
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

DiscoveryProbe? GPCR/G protein-related Compounds Panel

L1009-5 5 mg/well
EUR 7242
Description: A wide range of well-characterized bioactive molecules that covers various targets related to GPCR, including adenosine receptor, adrenergic receptor and CXCR etc. Facilitate your research towards the insights of cancer, neurological disorders and heart diseases etc.

Recombinant Human RAR-Related Orphan Receptor C

7-06163 5µg Ask for price

Recombinant Human RAR-Related Orphan Receptor C

7-06164 20µg Ask for price

Recombinant Human RAR-Related Orphan Receptor C

7-06165 1mg Ask for price

RAR Related Orphan Receptor Alpha (RORa) Antibody

20-abx103508
  • EUR 376.80
  • EUR 159.60
  • EUR 978.00
  • EUR 510.00
  • EUR 326.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx103509
  • EUR 510.00
  • EUR 159.60
  • EUR 1446.00
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx005288
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx119555
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

20-abx130085
  • EUR 543.60
  • EUR 159.60
  • EUR 1562.40
  • EUR 744.00
  • EUR 410.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rar-Related Orphan Receptor A (RORA) Antibody

20-abx115045
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Rar-Related Orphan Receptor B (RORB) Antibody

20-abx115046
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Rar-Related Orphan Receptor C (RORC) Antibody

20-abx115047
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Intermediate Filament Family Orphan 1 (IFFO1) Antibody

20-abx113262
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

RAR Related Orphan Receptor Gamma (RORG) Antibody

20-abx013514
  • EUR 376.80
  • EUR 117.60
  • EUR 477.60
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-400ul 400 ul
EUR 627.6

RAR Related Orphan Receptor Beta (RORB) Antibody

abx027769-80l 80 µl
EUR 343.2

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-400ul 400 ul
EUR 627.6

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx025951-80l 80 µl
EUR 343.2

Intermediate Filament Family Orphan 1 (IFFO1) Antibody

abx037159-100ug 100 ug
EUR 469.2

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx178212
  • EUR 1562.40
  • EUR 744.00
  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx338779
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

RAR Related Orphan Receptor Gamma (RORG) Protein

20-abx261968
  • EUR 5388.00
  • EUR 393.60
  • EUR 276.00
  • 1 mg
  • 20 ug
  • 5 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx325108
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Intermediate Filament Family Orphan 1 (IFFO1) Antibody

abx234132-100ug 100 ug
EUR 577.2

RAR Related Orphan Receptor Alpha (RORA) Antibody

20-abx211380
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

20-abx214131
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

RAR Related Orphan Receptor Beta (RORB) Antibody

20-abx214132
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Neuron Derived Orphan Receptor 1 (NOR1) Antibody

20-abx173779
  • EUR 1095.60
  • EUR 560.40
  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx174332
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Gamma (RORg) Antibody

20-abx174333
  • EUR 1095.60
  • EUR 560.40
  • 1 mg
  • 200 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody

abx237387-100ug 100 ug
EUR 610.8

RAR Related Orphan Receptor Beta (RORB) Antibody

abx237388-100ug 100 ug
EUR 610.8

PHOSPHO2 Phosphatase Orphan-2 Human Recombinant Protein

PROTQ8TCD6 Regular: 10ug
EUR 380.4
Description: PHOSPHO2 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 265 amino acids (1-241) and having a molecular mass of 30.3kDa.;PHOSPHO2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

PHOSPHO1 Phosphatase Orphan-1 Human Recombinant Protein

PROTQ8TCT1 Regular: 10ug
EUR 380.4
Description: Human Phospho1 Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 295 amino acids and having a molecular mass of 31.3 kDa. The Human Phospho1 is fused to a 14 aa His tag at N-Terminus. Human Phosphocholine Phosphatase is purified by proprietary chromatographic techniques.

Recombinant Neuron Derived Orphan Receptor 1 (NOR1)

4-RPC675Ra01
  • EUR 614.59
  • EUR 288.00
  • EUR 1974.72
  • EUR 738.24
  • EUR 1356.48
  • EUR 487.20
  • EUR 4756.80
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Neuron Derived Orphan Receptor 1 expressed in: E.coli

Recombinant RAR Related Orphan Receptor Alpha (RORa)

4-RPD947Hu01
  • EUR 580.19
  • EUR 278.40
  • EUR 1845.70
  • EUR 695.23
  • EUR 1270.46
  • EUR 463.20
  • EUR 4434.24
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human RAR Related Orphan Receptor Alpha expressed in: E.coli

Recombinant RAR Related Orphan Receptor Gamma (RORg)

4-RPD949Hu01
  • EUR 586.63
  • EUR 280.80
  • EUR 1869.89
  • EUR 703.30
  • EUR 1286.59
  • EUR 468.00
  • EUR 4494.72
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human RAR Related Orphan Receptor Gamma expressed in: E.coli

Cell Meter™ Beta-Arrestin Translocation GPCR Signaling Kit

36390 100 Tests
EUR 781

Cell Meter™ Beta-Arrestin Translocation GPCR Signaling Kit

36391 200 Tests
EUR 989

Rat Neuron Derived Orphan Receptor 1 (NOR1) Protein

20-abx167704
  • EUR 861.60
  • EUR 343.20
  • EUR 2665.20
  • EUR 1028.40
  • EUR 610.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human RAR Related Orphan Receptor Alpha (RORa) Protein

20-abx068824
  • EUR 811.20
  • EUR 326.40
  • EUR 2481.60
  • EUR 961.20
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human RAR Related Orphan Receptor Gamma (RORg) Protein

20-abx068825
  • EUR 828.00
  • EUR 343.20
  • EUR 2515.20
  • EUR 978.00
  • EUR 594.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Receptor Tyrosine Kinase-Like Orphan Receptor 1 Antibody

20-abx115089
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

RAR Related Orphan Receptor Alpha (RORA) Antibody (HRP)

20-abx336856
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody (FITC)

20-abx336857
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

RAR Related Orphan Receptor Alpha (RORA) Antibody (Biotin)

20-abx336858
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Rat RAR Related Orphan Receptor Gamma (RORg) Protein

20-abx654904