Tricarboxylic Acid Cycle Metabolites as Mediators of DNA

Greg June 29, 2021 0 Comments
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Tricarboxylic Acid Cycle Metabolites as Mediators of DNA Methylation Reprogramming in Bovine Preimplantation Embryos

  • In lots of cell varieties, epigenetic adjustments are partially regulated by the provision of metabolites concerned within the exercise of chromatin-modifying enzymes. Even so, the affiliation between metabolism and the everyday epigenetic reprogramming that happens throughout preimplantation embryo growth stays poorly understood.
  • On this work, we discover the hyperlink between vitality metabolism, extra particularly the tricarboxylic acid cycle (TCA), and epigenetic regulation in bovine preimplantation embryos.
  • Utilizing a morphokinetics mannequin of embryonic growth (fast- and slow-developing embryos), we present that DNA methylation (5mC) and hydroxymethylation (5hmC) are dynamically regulated and altered by the pace of the primary cleavages.
  • Extra particularly, slow-developing embryos fail to carry out the everyday reprogramming that’s vital to make sure the era of blastocysts with larger capability to determine particular cell lineages. Transcriptome evaluation revealed that such variations have been primarily related to enzymes concerned within the TCA cycle slightly than particular writers/erasers of DNA methylation marks.
  • This relationship was later confirmed by disturbing the embryonic metabolism by adjustments in α-ketoglutarate or succinate availability in tradition media. This was adequate to intrude with the DNA methylation dynamics even supposing blastocyst charges and whole cell quantity weren’t fairly affected.
  • These outcomes present the primary proof of a relationship between epigenetic reprogramming and vitality metabolism in bovine embryos. Likewise, ranges of metabolites in tradition media could also be essential for exact epigenetic reprogramming, with attainable additional penalties within the molecular management and differentiation of cells.

Tricarboxylic Acid Cycle Metabolites as Mediators of DNA Methylation Reprogramming in Bovine Preimplantation Embryos

  • In lots of cell varieties, epigenetic adjustments are partially regulated by the provision of metabolites concerned within the exercise of chromatin-modifying enzymes. Even so, the affiliation between metabolism and the everyday epigenetic reprogramming that happens throughout preimplantation embryo growth stays poorly understood.
  • On this work, we discover the hyperlink between vitality metabolism, extra particularly the tricarboxylic acid cycle (TCA), and epigenetic regulation in bovine preimplantation embryos.
  • Utilizing a morphokinetics mannequin of embryonic growth (fast- and slow-developing embryos), we present that DNA methylation (5mC) and hydroxymethylation (5hmC) are dynamically regulated and altered by the pace of the primary cleavages.
  • Extra particularly, slow-developing embryos fail to carry out the everyday reprogramming that’s vital to make sure the era of blastocysts with larger capability to determine particular cell lineages. Transcriptome evaluation revealed that such variations have been primarily related to enzymes concerned within the TCA cycle slightly than particular writers/erasers of DNA methylation marks.
  • This relationship was later confirmed by disturbing the embryonic metabolism by adjustments in α-ketoglutarate or succinate availability in tradition media. This was adequate to intrude with the DNA methylation dynamics even supposing blastocyst charges and whole cell quantity weren’t fairly affected.
  • These outcomes present the primary proof of a relationship between epigenetic reprogramming and vitality metabolism in bovine embryos. Likewise, ranges of metabolites in tradition media could also be essential for exact epigenetic reprogramming, with attainable additional penalties within the molecular management and differentiation of cells.
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Calf thymus DNA
T13592-1g 1g Ask for price
Description: Calf thymus DNA

Calf thymus DNA
T13592-1mg 1mg Ask for price
Description: Calf thymus DNA

Calf thymus DNA
T13592-50mg 50mg Ask for price
Description: Calf thymus DNA

Calf thymus DNA
T13592-5mg 5mg Ask for price
Description: Calf thymus DNA

Calf thymus DNA
MBS5754258-10mg 10mg
EUR 220

Calf thymus DNA
MBS5754258-25mg 25mg
EUR 365

Calf thymus DNA
MBS5754258-2mg 2mg
EUR 135

Calf thymus DNA
MBS5754258-50mg 50mg
EUR 625

Calf thymus DNA
MBS5754258-5mg 5mg
EUR 175

DNA, Denatured Calf Thymus
40490044-1 10 mg
EUR 65.14

DNA, Denatured Calf Thymus
40490044-2 20 mg
EUR 114.09

OORA00209-v1 - DNA (Calf Thymus)
OORA00209-v1 100mg
EUR 125

OORA00210-25MG - DNA (Calf Thymus)
OORA00210-25MG 25mg
EUR 179

OORA00209-100MG - DNA (Calf Thymus)
OORA00209-100MG 100mg
EUR 119

DNA, Calf Thymus (Deoxyribonucleic acid)
MBS653508-100mg 100mg
EUR 300

DNA, Calf Thymus (Deoxyribonucleic acid)
MBS653508-1g 1g
EUR 575

DNA, Calf Thymus (Deoxyribonucleic acid)
MBS653508-5g 5g
EUR 1925

DNA, Calf Thymus (Deoxyribonucleic acid)
MBS653508-5x5g 5x5g
EUR 8510

RNase-Free Calf Thymus DNA, 1 mg/mL (5x1mL)
9-31065
  • Ask for price
  • Ask for price
  • 1tube
  • 5tubes
Description: Minimum order quantity: 1 unit of 5tubes

RNase-Free Calf Thymus DNA, 1 mg/mL (1 mL)
31065-1 EA
EUR 261

BOVINE, CALF, THYMUS, FRESH
8601156 1G
EUR 67.09

BOVINE, CALF, THYMUS, FROZEN
8621156 1G
EUR 67.09

Calf Thymus Acetone Powder
E61A00101 5g
EUR 100

Calf Thymus Acetone Powder
E61A00102 10g
EUR 175

Calf Thymus Acetone Powder
E61A00103 100g
EUR 1500

Calf Thymus Acetone Powder
MBS8506722-5g 5g
EUR 680

Calf Thymus Acetone Powder
MBS8506722-5x5g 5x5g
EUR 2905

Calf Thymus Acetone Powder
MBS8506755-10g 10g
EUR 255

Calf Thymus Acetone Powder
MBS8506755-5x10g 5x10g
EUR 1005

Calf Thymus Acetone Powder
MBS8506831-100g 100g
EUR 1590

Calf Thymus Acetone Powder
MBS8506831-5x100g 5x100g
EUR 6995

Nucleohistone Thymus (calf)
N15210 100MG
EUR 578.7

La/SS-B Antigen, Calf Thymus
MBS651604-10mg 10mg
EUR 545

La/SS-B Antigen, Calf Thymus
MBS651604-5x10mg 5x10mg
EUR 2310

BOVINE, CALF, FETAL, THYMUS, FRESH
8601156.2 1G
EUR 81.74

BOVINE, CALF, FETAL, THYMUS, FROZEN
8621156.2 1G
EUR 81.74

Deoxyribonucleic acid sodium salt from calf thymus
abx082051-100mg 100 mg
EUR 276

Deoxyribonucleic Acid Sodium Salt from Calf Thymus
05658-44 100MG
EUR 42.7

Deoxyribonucleic acid sodium salt from calf thymus
abx082051-100l 100 µl
EUR 200

Deoxyribonucleic acid sodium salt from calf thymus
abx082051-1ml 1 ml Ask for price

Deoxyribonucleic acid sodium salt from calf thymus
abx082051-200l 200 µl Ask for price

Purified Native dsDNA, Calf Thymus, ELISA/Antigen grade
DNAD25-N-1 1 mg
EUR 196.8

Purified Native ssDNA, Calf Thymus, ELISA/Antigen grade
DNAS35-N-1 1 mg
EUR 270

Deoxyribonucleic Acid Sodium Salt (DNA Sodium Salt Highly Polymerized) ex. Calf Thymus extrapure
68451 25 Mg
EUR 20.63
Description: Part B

Deoxyribonucleic acid (sodium, from calf thymus, Type I, fibers)
HY-153118 10 mg
EUR 54.11
Description: Deoxyribonucleic acid (sodium, from calf thymus, Type I, fibers) is the sodium salts form of Calf thymus DNA (HY-109517). Calf thymus DNA is a double-stranded template DNA isolated from calf thymus. It can be used to study the interaction between DNA and DNA binding agents, as well as the structure and function of DNA, for DNA quantification and used as a substrate for DNA polymerase analysis, etc​[1][2][3].

Human Thymus Genomic DNA
HG-702 0.05mg
EUR 210

Genomic DNA - Rat Normal Tissue: Thymus
D1434264 100 ug
EUR 329

Mouse Thymus, match set of RNA, DNA, Protein
MS-702-RDP 20µg/20µg/100µg
EUR 422

Tissue, Genomic DNA, Rat Adult Normal, Thymus, BioGenomics
MBS654456-01mg 0.1mg
EUR 575

Tissue, Genomic DNA, Rat Adult Normal, Thymus, BioGenomics
MBS654456-5x01mg 5x0.1mg
EUR 2440

Thymus Lysate
1471 0.1 mg
EUR 229.2
Description: Thymus tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 50 mM DTT.

Thymus Factor
GWB-A72648 1 mg Ask for price

Thymus Factor
070-77 500 μg
EUR 50.76

Thymus, Rabbit
MBS639337-25Each 25Each
EUR 370

Thymus, Rabbit
MBS639337-5x25Each 5x25Each
EUR 1450

Thymus Factor
MBS826394-10mg 10mg
EUR 290

Thymus Factor
MBS826394-1mg 1mg
EUR 150

Thymus Factor
MBS826394-5mg 5mg
EUR 215

Thymus Factor
MBS826394-5x10mg 5x10mg
EUR 1195

Thymus Lysate
MBS151621-01mg 0.1mg
EUR 200

Thymus Lysate
MBS151621-5x01mg 5x0.1mg
EUR 880

Thymus Lysate
MBS151715-01mg 0.1mg
EUR 200

Thymus Lysate
MBS151715-5x01mg 5x0.1mg
EUR 880

Thymus Lysate
MBS151748-01mg 0.1mg
EUR 200

Thymus Lysate
MBS151748-5x01mg 5x0.1mg
EUR 880

Dog Thymus RNA*
DR-702 0.05mg
EUR 195

Dog Thymus cDNA*
DD-702 30 Reactions
EUR 319

Cat Thymus cDNA
FD-702 30 Reactions
EUR 319

Pig Thymus cDNA
PD-702 30 reactions
EUR 243

Rat Thymus cDNA
RD-702 30 reactions
EUR 243

Thymus factor X
HY-P0001 1mg
EUR 357.6

Thymus factor X
TP1030-10mg 10mg Ask for price
Description: Thymus factor X

Thymus factor X
TP1030-1g 1g Ask for price
Description: Thymus factor X

Thymus factor X
TP1030-1mg 1mg Ask for price
Description: Thymus factor X

Thymus factor X
TP1030-50mg 50mg Ask for price
Description: Thymus factor X

Thymus factor X
TP1030-5mg 5mg Ask for price
Description: Thymus factor X

Thymus factor X
MBS5763355-1mg 1mg
EUR 240

Thymus factor X
MBS5763355-5mg 5mg
EUR 690

Thymus factor X
MBS5763355-5x5mg 5x5mg
EUR 2950

Thymus peptide C
HY-P0070 5mg
EUR 639.6

Sheep Thymus cDNA
SD-702 30 reactions
EUR 243

Thymus peptide C
TP1694-10mg 10mg Ask for price
Description: Thymus peptide C

Thymus peptide C
TP1694-1g 1g Ask for price
Description: Thymus peptide C

Thymus peptide C
TP1694-1mg 1mg Ask for price
Description: Thymus peptide C

Thymus peptide C
TP1694-50mg 50mg Ask for price
Description: Thymus peptide C

Thymus peptide C
TP1694-5mg 5mg Ask for price
Description: Thymus peptide C

Thymus peptide C
MBS5763744-5mg 5mg
EUR 375

Thymus peptide C
MBS5763744-5x5mg 5x5mg
EUR 1530

Equine Thymus cDNA
ED-702 30 reactions
EUR 319

Bovine Thymus cDNA
BD-702 30 reactions
EUR 243

Rabbit Thymus cDNA
TD-702 30 reactions
EUR 243

PARG (bovine thymus)
MBS566099-01Unit 0.1Unit
EUR 640

PARG (bovine thymus)
MBS566099-5x01Unit 5x0.1Unit
EUR 2815

Thymus Tissue block
26 1 unit
EUR 635

Chicken Thymus cDNA*
CD-702 30 reactions
EUR 243

Hamster Thymus cDNA
AD-702 30 reactions
EUR 243

Fetal Thymus Lysate
XBL-10426 0.1 mg
EUR 500.1
Description: Fetal human thymus tissue lysate was prepared by homogenization using a proprietary technique. The tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The fetal human thymus tissue total protein is provided in a buffer including HEPES (pH7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, Sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the thymus tissue pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The thymus tissue is then Western analyzed by either GAPDH or β-actin antibody, and the expression level is consistent with each lot.

MiniPig Thymus cDNA
ND-702 30 reactions
EUR 446

Thymus Powder (porcine)
PTP-010 1kg
EUR 525

Thymus Membrane Lysate
XBL-10978 0.1 mg
EUR 991.5
Description: Human thymus tissue membrane protein lysate was prepared by isolating the membrane protein from whole tissue homogenates using a proprietary technique. The human thymus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The membrane protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, Glycerol, sodium deoxycholate, NP-40, and a cocktail of protease inhibitors. For quality control purposes, the isolated thymus tissue membrane protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated thymus tissue membrane protein is then Western analyzed by either GAPDH or β-actin antibody to confirm there is no signal or very weak signal.

OORA00348-10U - THYMUS
OORA00348-10U 1Each
EUR 155

OORA00348-1EA - THYMUS
OORA00348-1EA 1Each
EUR 149

OORA00490-10U - THYMUS
OORA00490-10U 1Each
EUR 55

OORA00490-1EA - THYMUS
OORA00490-1EA 1Each
EUR 59

Chicken Thymus Sections
CP-702 10 slides
EUR 240

Thymus Cytoplasmic Lysate
XBL-10977 0.1 mg
EUR 273.3
Description: Human thymus tissue cytoplasmic protein lysate was prepared by isolating the cytoplasmic protein from whole tissue homogenates using a proprietary technique. The human thymus tissue was frozen in liquid nitrogen immediately after excision and then stored at -70°C. The cytoplasmic protein is provided in a buffer including HEPES (pH 7.9), MgCl2, KCl, EDTA, Sucrose, glycerol, and a cocktail of protease inhibitors. For quality control purposes, the isolated thymus tissue cytoplasmic protein pattern on SDS-PAGE gel is shown to be consistent for each lot by visualization with coomassie blue staining. The isolated thymus tissue cytoplasmic protein is then Western analyzed by GAPDH antibody, and the expression level is consistent with each lot.

Cat Thymus Total RNA*
FR-702 0.05mg
EUR 195

Pig Thymus Total RNA
PR-702 0.1mg
EUR 160

Rat Thymus Total RNA
RR-702 0.05mg
EUR 160

Mouse CD1 Thymus cDNA
MD-702 30 reactions
EUR 243

Mouse BLC Thymus cDNA
MD-702-BLC 30 reactions
EUR 280

Mouse C57 Thymus cDNA
MD-702-C57 30 reactions
EUR 280

Human Thymus Total RNA
HR-702 0.05mg
EUR 172

Guinea Pig Thymus cDNA
GD-702 30 reactions
EUR 243

Sheep Thymus Total RNA
SR-702 0.1mg
EUR 160

Bovine Thymus Total RNA
BR-702 0.1mg
EUR 160

Equine Thymus Total RNA
ER-702 0.1mg
EUR 195

Rabbit Thymus Total RNA*
TR-702 0.05mg
EUR 160

Dog Thymus Total Protein
DT-702 1mg
EUR 176

Hamster Thymus Total RNA*
AR-702 0.05mg
EUR 160

Chicken Thymus Total RNA*
CR-702 0.05mg
EUR 160

Cat Thymus Total Protein
FT-702 1mg
EUR 176

Pig Thymus Total Protein
PT-702 1mg
EUR 153

MiniPig Thymus Total RNA
NR-702 0.1mg
EUR 319

Rat Thymus Tissue Lysate
LYSATE0008 200ug
EUR 180
Description: This cell lysate is prepared from rat thymus tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.

Rat Thymus Total Protein
RT-702 0.5mg
EUR 153

OORA00549-1U - Rat THYMUS
OORA00549-1U 1Each
EUR 60

Monkey Thymus cDNA, Rhesus
UD-702 30 reactions
EUR 316

Dna Calf Activated Di - EACH
27457501 EACH
EUR 409.05

Dog Thymus Frozen Sections
DF-702 10 slides
EUR 261

Cat Thymus Frozen Sections
FF-702 10 slides
EUR 261

Human Thymus Tissue Lysate
IHUTYMTL100UG each
EUR 245
Description: Human Thymus Tissue Lysate

OORA00549-1EA - Rat THYMUS
OORA00549-1EA 1Each
EUR 59

Pig Thymus Frozen Sections
PF-702 10 slides
EUR 261

Mouse Thymus Tissue Lysate
LYSATE0019 200ug
EUR 180
Description: This cell lysate is prepared from mouse thymus tissue using Boster's RIPA Lysis Buffer (AR0105) using a standard whole cell lysate protocol. The concentration was determined using the BCA assay process and then diluted using Dithiothreitol (DTT) and a reducing SDS sample loading buffer, heated for 5 minutes at 100˚C.

Chloroplast growth and genomes uncoupled signaling are impartial of the RNA-directed DNA methylation pathway

The Arabidopsis genome is methylated in CG and non-CG (CHG, and CHH wherein H stands for A, T, or C) sequence contexts. DNA methylation has been urged to be essential for seed growth, and CHH methylation patterns change throughout stratification and germination. In vegetation, CHH methylation happens primarily by the RNA-directed DNA methylation (RdDM) pathway.

To take a look at for an involvement of the RdDM pathway in chloroplast growth, we analyzed seedling greening and the utmost quantum yield of photosystem II (Fv/Fm) in Arabidopsis thaliana seedlings perturbed in elements of that pathway. Neither seedling greening nor Fv/Fm in seedlings and grownup vegetation have been affected on this complete set of mutants, indicating that alterations within the RdDM pathway don’t have an effect on chloroplast growth.

Utility of inhibitors like lincomycin or norflurazon inhibits greening of seedlings and represses the expression of photosynthesis-related genes together with LIGHT HARVESTING CHLOROPHYLL A/B BINDING PROTEIN1.2 (LHCB1.2) within the nucleus. Our outcomes point out that the LHCB1.2 promoter is poorly methylated beneath each management circumstances and after inhibitor therapy.

Subsequently no correlation between LHCB1.2 mRNA transcription and methylation adjustments of the LHCB1.2 promoter might be established. Furthermore, we conclude that perturbations within the RdDM pathway don’t intrude with gun signaling.

DNA minor-groove binder Hoechst 33258 destabilizes base-pairing adjoining to its binding web site

 

Understanding the dynamic interactions of ligands to DNA is vital in DNA-based nanotechnologies. By structurally monitoring the dissociation of Hoechst 33258-bound DNA (d(CGCAAATTTGCG)2) advanced (H-DNA) with T-jump 2D-IR spectroscopy, the ligand is discovered to strongly disturb the steadiness of the three C:G base pairs adjoining to A:T the binding web site, with the damaged base pairs being greater than triple at 100 ns.

The robust stabilization impact of the ligand on DNA duplex makes this statement fairly placing, which dramatically will increase the melting temperature and dissociation time. MD simulations show an vital position of hydration water and counter cations in sustaining the separation of terminal base pairs. The hydrogen bonds between the ligand and thymine carbonyls are essential in stabilizing H-DNA, whose breaking sign showing previous to the whole dissociation. Thermodynamic evaluation informs us that H-DNA affiliation is a concerted course of, the place H cooperates with DNA single strands in forming H-DNA.

BLU-554
B8391-100 100mg
EUR 1507

BLU-554
B8391-5 5mg
EUR 174

BLU-554
B8391-50 50mg
EUR 870

BLU-554
B2359-1 each
EUR 144

BLU-554
B2359-5 each
EUR 392.4

BLU-554
MBS131490-100mg 100mg
EUR 1495

BLU-554
MBS579587-100mg 100mg
EUR 990

BLU-554
MBS579587-10mg 10mg
EUR 260

BLU-554
MBS579587-1mg 1mg
EUR 155

BLU-554
MBS579587-50mg 50mg
EUR 605

BLU-554
MBS579587-5mg 5mg
EUR 195

BLU-554
MBS3602606-10mg 10mg
EUR 390

BLU-554
MBS3602606-25mg 25mg
EUR 725

BLU-554
MBS3602606-2mg 2mg
EUR 250

BLU-554
MBS3602606-5mg 5mg
EUR 315

BLU-554
MBS3602606-5x25mg 5x25mg
EUR 2945

BLU-9931
MBS130781-100mg 100mg
EUR 1065

BLU-9931
MBS130781-500mg 500mg
EUR 2775

BLU-263
T9295-10mg 10mg Ask for price
Description: BLU-263

BLU-263
T9295-1g 1g Ask for price
Description: BLU-263

BLU-263
T9295-1mg 1mg Ask for price
Description: BLU-263

BLU-945
T9754-10mg 10mg Ask for price
Description: BLU-945

BLU-945
T9754-1g 1g Ask for price
Description: BLU-945

BLU-945
T9754-1mg 1mg Ask for price
Description: BLU-945

BLU-945
T9754-50mg 50mg Ask for price
Description: BLU-945

BLU-945
T9754-5mg 5mg Ask for price
Description: BLU-945

BLU-263
T9295-50mg 50mg Ask for price
Description: BLU-263

BLU-263
T9295-5mg 5mg Ask for price
Description: BLU-263

Blu-782
T8108-10mg 10mg Ask for price
Description: Blu-782

Blu-782
T8108-1g 1g Ask for price
Description: Blu-782

Blu-782
T8108-1mg 1mg Ask for price
Description: Blu-782

Blu-782
T8108-50mg 50mg Ask for price
Description: Blu-782

Blu-782
T8108-5mg 5mg Ask for price
Description: Blu-782

BLU-945
MBS5801399-10mg 10(mg
EUR 895

BLU-945
MBS5801399-1mg 1(mg
EUR 325

BLU-945
MBS5801399-5mg 5(mg
EUR 540

BLU-263
MBS5786217-10mg 10(mg
EUR 470

BLU-263
MBS5786217-1mg 1(mg
EUR 210

BLU-263
MBS5786217-5mg 5(mg
EUR 335

BLU-782
MBS132903-INQUIRE INQUIRE Ask for price

Blu-782
MBS3611166-10mg 10mg
EUR 495

Blu-782
MBS3611166-25mg 25mg
EUR 775

Blu-782
MBS3611166-5mg 5mg
EUR 345

Blu-782
MBS3611166-5x25mg 5x25mg
EUR 3185

Blu-782
MBS5758933-10mg 10mg
EUR 430

Blu-782
MBS5758933-1mg 1mg
EUR 185

Blu-782
MBS5758933-25mg 25mg
EUR 715

Blu-782
MBS5758933-5mg 5mg
EUR 280

Blu-782
MBS5758933-5x25mg 5x25mg
EUR 3070

BLU-945
HY-144680 10 mg
EUR 1385.3
Description: BLU-945 is a potent, highly selective, reversible and orally active epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKIs). BLU-945 can effectively inhibit EGFR with L858R and/or exon 19 deletion mutation, T790M mutation and C797S mutation. BLU-945 can be used for the research of lung cancer including non-small cell lung cancer (NSCLC)[1][2][3].

Blu 9931
20-abx183889
  • Ask for price
  • Ask for price
  • 100 mg
  • 10 mg

BLU antibody
22462 100ul
EUR 479

BLU antibody
22462-100ul 100ul
EUR 468

BLU antibody
70R-13110 100 ul
EUR 550
Description: Affinity purified Rabbit polyclonal BLU antibody

BLU antibody
MBS9410938-01mL 0.1mL
EUR 420

BLU antibody
MBS9410938-5x01mL 5x0.1mL
EUR 1740

BLU antibody
MBS835407-01mL 0.1mL
EUR 1070

BLU antibody
MBS835407-5x01mL 5x0.1mL
EUR 4655

BLU-667 (Pralsetinib)
B2548-1 each
EUR 170.4

BLU-667 (Pralsetinib)
B2548-5 each
EUR 496.8

Avapritinib?BLU-285
MBS131631-100mg 100mg
EUR 1065

Avapritinib?BLU-285
MBS131631-500mg 500mg
EUR 2925

Recombinant Human BLU
MBS7608948-005mg 0.05mg
EUR 470

Recombinant Human BLU
MBS7608948-02mg 0.2mg
EUR 885

Recombinant Human BLU
MBS7608948-1mg 1mg
EUR 2540

Recombinant Human BLU
MBS7608948-5x1mg 5x1mg
EUR 9820

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu)
MBS6008009-02mL 0.2(mL
EUR 695

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu)
MBS6008009-5x02mL 5x0.2mL
EUR 2975

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu)
MBS6011271-02mL 0.2(mL
EUR 695

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu)
MBS6011271-5x02mL 5x0.2mL
EUR 2975

Rat Bluetongue virus(Blu)ELISA Kit
SL1336Ra - Ask for price

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (AP)
MBS6365458-02mL 0.2mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (AP)
MBS6365458-5x02mL 5x0.2mL
EUR 4250

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (APC)
MBS6365459-02mL 0.2mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (APC)
MBS6365459-5x02mL 5x0.2mL
EUR 4250

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (PE)
MBS6365468-02mL 0.2mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (PE)
MBS6365468-5x02mL 5x0.2mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (AP)
MBS6365469-02mL 0.2mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (AP)
MBS6365469-5x02mL 5x0.2mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (APC)
MBS6365470-02mL 0.2mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (APC)
MBS6365470-5x02mL 5x0.2mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (PE)
MBS6365479-02mL 0.2mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (PE)
MBS6365479-5x02mL 5x0.2mL
EUR 4250

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (FITC)
MBS6365461-02mL 0.2mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (FITC)
MBS6365461-5x02mL 5x0.2mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (FITC)
MBS6365472-02mL 0.2mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (FITC)
MBS6365472-5x02mL 5x0.2mL
EUR 4250

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (Biotin)
MBS6365460-02mL 0.2mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (Biotin)
MBS6365460-5x02mL 5x0.2mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (Biotin)
MBS6365471-02mL 0.2mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (Biotin)
MBS6365471-5x02mL 5x0.2mL
EUR 4250

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 405)
MBS6365463-01mL 0.1mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 405)
MBS6365463-5x01mL 5x0.1mL
EUR 4250

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 490)
MBS6365464-01mL 0.1mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 490)
MBS6365464-5x01mL 5x0.1mL
EUR 4250

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 550)
MBS6365465-01mL 0.1mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 550)
MBS6365465-5x01mL 5x0.1mL
EUR 4250

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 650)
MBS6365466-01mL 0.1mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 650)
MBS6365466-5x01mL 5x0.1mL
EUR 4250

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 750)
MBS6365467-01mL 0.1mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 750)
MBS6365467-5x01mL 5x0.1mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 405)
MBS6365474-01mL 0.1mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 405)
MBS6365474-5x01mL 5x0.1mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 490)
MBS6365475-01mL 0.1mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 490)
MBS6365475-5x01mL 5x0.1mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 550)
MBS6365476-01mL 0.1mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 550)
MBS6365476-5x01mL 5x0.1mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 650)
MBS6365477-01mL 0.1mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 650)
MBS6365477-5x01mL 5x0.1mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 750)
MBS6365478-01mL 0.1mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (MaxLight 750)
MBS6365478-5x01mL 5x0.1mL
EUR 4250

BLU (ZMYND10) (NM_015896) Human Recombinant Protein
PROTO75800 20ug
EUR 1249
Description: Recombinant protein of human zinc finger, MYND-type containing 10 (ZMYND10)

Human Blue-tongue virus (BLU) ELISA Kit
SL3344Hu 96 Tests
EUR 468

Bovine Blue-tongue virus (BLU) ELISA Kit
SL0058Bo -
EUR 528

PAST B7541 Ø25(7) BLU 2022 AB Labels
834795 Pack of 175 Label(s)
EUR 114.92
Description: Description Dutch: Vervaldagaanduiding-DATE 22 Dia 25 B-7541; Description French: PASTILLES CALENDRIER 22 Dia 25 B-7541

PAST B7541 Ø25(7) BLU 2029 AB Labels
834802 Pack of 175 Label(s)
EUR 114.92
Description: Description Dutch: Vervaldagaanduiding-DATE 29 Dia 25 B-7541; Description French: PASTILLES CALENDRIER 29 Dia 25 B-7541

PAST B7541 Ø35(5) BLU 2022 AB Labels
834813 Pack of 125 Label(s)
EUR 114.92
Description: Description Dutch: Vervaldagaanduiding-DATE 22 Dia 35 B-7541; Description French: PASTILLES CALENDRIER 22 Dia 35 B-7541

PAST B7541 Ø35(5) BLU 2029 AB Labels
834820 Pack of 125 Label(s)
EUR 114.92
Description: Description Dutch: Vervaldagaanduiding-DATE 29 Dia 35 B-7541; Description French: PASTILLES CALENDRIER 29 Dia 35 B-7541

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (Azide free) (HRP)
MBS6365462-02mL 0.2mL
EUR 980

ZMYND10, CT (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (Azide free) (HRP)
MBS6365462-5x02mL 5x0.2mL
EUR 4250

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (Azide free) (HRP)
MBS6365473-02mL 0.2mL
EUR 980

ZMYND10, ID (ZMYND10, BLU, Zinc finger MYND domain-containing protein 10, Protein BLu) (Azide free) (HRP)
MBS6365473-5x02mL 5x0.2mL
EUR 4250

RPL 554
R700940 250mg
EUR 9200
Description: 1884461-72-6

Kinesis Tub FEP Blu .124 x .062 - 1INCH
CHR4691 1INCH
EUR 2.7

Kinesis Tub PEEK Blu .062 x .030 - 1INCH
CHR4735 1INCH
EUR 2.7

Kinesis Tub PEEK Blu .062 x .010 - 1INCH
CHR4751 1INCH
EUR 2.7

Kinesis Tub PEEK Blu .0305 x .010 - 1INCH
CHR4769 1INCH
EUR 4.05

PAST B500 57X25(9) BLU 2022 AB Labels
834278 Pack of 225 Label(s)
EUR 130.11
Description: Description Dutch: Vervaldagaanduiding-DATE 22 57x25 B-500; Description French: PASTILLES CALENDRIER 22 57x25 B-500

PAST B500 57X25(9) BLU 2029 AB Labels
834285 Pack of 225 Label(s)
EUR 130.11
Description: Description Dutch: Vervaldagaanduiding-DATE 29 57x25 B-500; Description French: PASTILLES CALENDRIER 29 57x25 B-500

Edge Blu pH meter with HALO - EACH
PHE1038 EACH
EUR 918

Kinesis MicroTight Slv Blu .011 x .025 - EACH
CHR3373 EACH
EUR 8.1

C.L.E.D HiCynth Agar w/ Bromo Thymol Blu
MCD792-100G 1 unit
EUR 16.93
Description: C.L.E.D HiCynth Agar w/ Bromo Thymol Blu

C.L.E.D HiCynth Agar w/ Bromo Thymol Blu
MCD792-500G 1 unit
EUR 43.24
Description: C.L.E.D HiCynth Agar w/ Bromo Thymol Blu

2ml CPKit Lyo Stopper Blu FlpOff Seal
VIA1048 1KIT
EUR 2848.21

2ml CPKit Omni Stopper Blu FlpOff Seal
VIA1020 1KIT
EUR 2770.92

10ml CPKit Omni Stopper Blu FlpOff Seal
VIA1040 1KIT
EUR 3007.95

2ml CPKit Uncoat Stopper Blu FlpOf Seal
VIA1044 1KIT
EUR 2551.92

10ml CPKit Uncoat Stopper Blu FlpOf Seal
VIA1028 1KIT
EUR 2788.95

DNase Test HiCynth Agar w/ Toluidine Blu
MCD1041-100G 1 unit
EUR 32.09
Description: DNase Test HiCynth Agar w/ Toluidine Blu

TAG -4 12 BLU BE Modernotecnica Consumables
SAB412 Pack of 1026 Tag(s)
EUR 60.56
Description: Description Dutch: Blauwe ACS-tag, 4 x 12 mm met 3 stroken; Description French: Etiquette ACS bleue, 3 rangées, 4 x 12 mm

Mouse Bluetongue virus(Blu)ELISA Kit定性
SL0810Mo - Ask for price

BLU (ZMYND10) (NM_015896) Human Over-expression Lysate
LS051364 100ug
EUR 628
Description: Transient overexpression lysate of zinc finger, MYND-type containing 10 (ZMYND10)

POUCHES WITH MAG. LOOPS BLU 295X330MM AB Labels
224061 Pack of 10 Piece(s)
EUR 113.97
Description: Description Dutch: Insteekhoezen met magneetlussen; Description French: Porte-documents avec anneaux magnétiques

POUCHES WITH MAG. LOOPS BLU 155X220MM AB Labels
224062 Pack of 10 Piece(s)
EUR 89.55
Description: Description Dutch: Insteekhoezen met magneetlussen; Description French: Porte-documents avec anneaux magnétiques

Rat Bluetongue virus antibody (Blu-Ab) ELISA Kit
SL1337Ra - Ask for price

Bovine Bluetongue virus antibody (Blu-Ab) ELISA Kit
SL0118Bo - Ask for price

anti-BLU
YF-PA19006 50 ug
EUR 435.6
Description: Mouse polyclonal to BLU

Rack 25 places for 5mL tubes blu - PK5
RAC2000 PK5
EUR 68.85

5ml CP Kit Lyo Stopper Blu FlpOff Seal
VIA1024 1KIT
EUR 2957.71

5ml CP Kit Omni Stopper Blu FlpOff Seal
VIA1032 1KIT
EUR 2889.43

10ml CP Kit Lyo Stopper Blu FlpOff Seal
VIA1036 1KIT
EUR 3076.22

Labsit 4 Foam w castors/ring Blu - EACH
FUR3540 EACH
EUR 427.42

5ml CP Kit Uncoat Stopper Blu FlpOf Seal
VIA1052 1KIT
EUR 2670.44

Sheep Blue-tongue virus (BLU) ELISA Kit 定性
SL00034Sp -
EUR 528

Rabbit Blue-tongue virus (BLU) ELISA Kit 定性
SL0255Rb -
EUR 498

Kinesis Adapt Body PEEK Blu 1/16x360um - EACH
CHR4617 EACH
EUR 39.15

SML POUCHES W/MAG. STRIP BLU 305X225MM AB Labels
224058 Pack of 10 Piece(s)
EUR 108.53
Description: Description Dutch: Grote insteekhoezen met magneetstrip op rugzijde; Description French: Porte-documents avec bande magnétique au dos

SML POUCHES W/MAG. STRIP BLU 157X220MM AB Labels
224059 Pack of 10 Piece(s)
EUR 84.58
Description: Description Dutch: Grote insteekhoezen met magneetstrip op rugzijde; Description French: Porte-documents avec bande magnétique au dos

SML POUCHES W/MAG. STRIP BLU 110X220MM AB Labels
224060 Pack of 10 Piece(s)
EUR 69.64
Description: Description Dutch: Grote insteekhoezen met magneetstrip op rugzijde; Description French: Porte-documents avec bande magnétique au dos

BLU (ZMYND10) (Center) rabbit polyclonal antibody, Aff - Purified
AP54658PU-N 400 µl Ask for price

BP 554 Maleate
B676723 500mg
EUR 4500
Description: 1221401-95-1

BP 554 maleate
B6351-10 10 mg
EUR 183
Description: Selective 5-HT1A agonist

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